can phentermine cause depression

Can phentermine cause depression?

December 14. 2022

We are in an era where mental health awareness finally became a thing. And it’s not a secret that some weight loss supplements, like phentermine, can cause depression. We understand that losing weight can be challenging for some people, especially if they suffer from obesity, so we want you to use all the possible means to achieve your goal safely. But what happens when you neglect your mental health while taking care of your physical health?

Weight loss supplements, even the approved ones, can provoke side effects and impact your mood. The experts from our weight loss clinic in Chicago advise you to always consult with a doctor about the right supplements for you. You should also schedule regular doctor visits to check the drug’s effect on your body. If you are eligible to use phentermine, you can start taking it and benefit from the aid this drug gives. In this article, we provide all the information you need to know regarding phentermine’s potential side effects on your mental health. If you feel like the drug is provoking undesirable effects, talk to your doctor immediately, even before stopping the use.

Weight loss medication and mental health

Losing weight is not an easy task, especially when you are bombed by images of “ideal bodies” all over social media and the news. Beauty standards often play against us and deviate our eyes from the real goal: losing weight to live a healthier and happier life. Under the pressure of losing weight quickly, some people turn to not approved drugs or supplements that can potentially put their health in danger and prejudice their mental health. Some people even opt for buying over-the-counter medications. Taking drugs without a prescription is highly discouraged. A healthcare professional will recommend you the right supplement for your specific needs. They will also advise you about the correct dosage, the potential side effects, and how to treat them. Phentermine is one of the most popular weight loss supplements prescripted by doctors. These approved weight loss pills can do wonders to boost your weight loss journey.

How does phentermine impact the brain?

Phentermine is a weight loss supplement approved by the Food and Drug Administration (FDA). This drug is currently one of the most popular and successful weight loss pills in the U.S. Phentermine is a stimulant; it works by stimulating your central nervous system. It takes part in a family of drugs called anorectics. Phentermine stimulates your nervous system, releasing specific neurotransmitters – dopamine, norepinephrine, and serotonin. Those chemicals cause appetite suppression. With a reduced appetite, you will be less hungry and won’t suffer as many cravings; your carbs intake will also decrease. In combination with the proper diet and a workout plan, phentermine can make you lose weight fast. Not everyone is eligible for this drug, though. It is aimed at people with a high percentage of body mass index or those suffering from obesity.

Like most drugs, phentermine can provoke side effects. The most common phentermine side effects include dry mouth, unpleasant taste in the mouth, constipation, nausea, vomiting, and headache. Of course, not every patient develops the same symptoms; some patients are not bothered by any of those side effects while on the drug. On the other hand, phentermine can also cause more severe side effects. Those include high blood pressure, increased heart rate, insomnia, sleeplessness, and jitteriness. This drug directly affects your central nervous system, meaning your brain is impacted by it. In some people, phentermine can also cause mood changes such as irritability, nervousness, and agitation. Dizziness and confusion are other uncommon but potential side effects. Also, impotence and a libido decrease can be provoked by the drug. While not very common, a few patients have reported suffering from depression due to their phentermine intake.

Phentermine and depression: Is there a connection?

Can phentermine cause depression? There is no direct connection between using phentermine for weight loss and suffering from depression. There are not enough studies on the subject, and while phentermine can have an effect on your mood, it is not proven that it provokes depression in its users. Still, a few users are said to have suffered from depression during or after taking phentermine for weight loss.

Phentermine depression, while rare, can occur. One of the most typical reasons why phentermine depression happens is due to the common side effects phentermine provokes. Insomnia and sleeplessness can lead to countless nights without proper rest. Our brains need at least eight hours of sleep each night to function correctly. Not getting enough sleep can make you irritated, angry, and sad. If these mood changes are added to the mood swings phentermine can cause, you can feel like your feelings are on a roller coaster – all that can lead to depression. It is not phentermine the one responsible for your depressed state of mind, but it indirectly provokes it through its multiple side effects. Impotence or a decrease in libido can also make you nervous or anxious about your sex life. If you don’t fully comprehend that all these side effects happen due to this weight loss drug, you can feel frustrated and with low self-esteem, which can also lead to depression. Phentermine side effects are manageable and tend to disappear once you are off the drug. If you suffer from one of those side effects for too long, contact your doctor right away. Maybe they need to adjust your dosage or take you off the drug. Never increase or decrease the dosage yourself; it can be dangerous for your health. And, instead of making the side effects disappear, it can make them worse.

In the few patients that reported depression as a side effect of taking phentermine, this mental health disorder occurred when they stopped taking the drug. Phentermine can be a habit-forming drug, and it can lead to addiction. It is vital to never take phentermine without a prescription and regular checkups from a professional. You should know that this weight loss supplement can only be prescribed for a short period, generally only a few weeks. It is meant to help you kickstart your weight loss journey. It is meant to help you kickstart your weight loss journey. After that initial phase – where you should see significant results – you must achieve weight loss goals by resorting to other tools: a good diet, exercise, and maybe another type of weight loss aid. When patients take phentermine longer than advised, that can lead to addiction. Once they stop taking the drug, they suffer from withdrawal symptoms, which can also take them to a depression disorder.

6 tips to prevent and cure phentermine depression

Avoid phentermine interactions

Phentermine can interact with other drugs or substances, creating unpleasant side effects in your body. A drug interaction is a reaction between two (or more) substances; it can lead to dangerous side effects or even change the way a drug is supposed to act. If you are on any other medication, provide your doctor with a list of those drugs before you start taking phentermine. Phentermine may interact with some common antidepressants and other weight loss supplements.

Phentermine and alcohol can interact. Alcohol is a depressant, and phentermine is a stimulant – meaning they have opposite effects. The hyperactivity caused by the stimulant and the drowsiness provoked by the alcohol can create unwanted effects and potentially lead to depression. It is recommended to avoid consuming alcoholic drinks while taking any medication.

Physical exercise

Staying active will help you lose weight faster and will also aid you in tackling any depression symptoms. Exercise makes your brain release endorphins and other chemicals that improve mood and make you feel more energized. Thirty minutes a day is a great way to beat depression and other mental disorders such as anxiety. If you can’t commit to half an hour each day, start with only 10 minutes and then upgrade your routine as you get more used to exercising. Any physical activity will help. Play your favorite sport with friends – sharing that moment with other people will also help you boost your mood. Go out for a morning run or walk. Sign in to a gym, or you can also do your favorite workout routine at home. Staying active will improve your mood, and you will feel even better when you start seeing how it improves your weight loss journey.

Get enough sleep

Phentermine can cause side effects such as sleeplessness and nervousness. Because of that, it’s recommended you get your phentermine dose in the morning. Getting a good night of rest can become difficult while taking the drug. Do your best to maintain a good sleep cycle. Try sticking to a proper sleep schedule; go to bed at the same time every night – ideally, not too late. And also wake up at about the same time every morning. Try not to stay awake more than necessary at night, and don’t oversleep in the mornings – all that can ruin your sleeping schedule. Leave your phone and avoid white light screens for at least 60 minutes before sleep. Instead, use that time to read a book or write in a journal; this will reduce your stress and help you get better sleep.

Try to cut down on coffee, sodas, and energy drinks if you have trouble sleeping. Mixing caffeine and phentermine can lead to troubles and dangerous side effects. Both substances are stimulants. It’s been proved that over-stimulation can lead to depression and anxiety. Reducing your caffeine intake while on the drug can help dodge that bullet.

Stay connected

When feeling sad or depressed, people tend to isolate themselves. Avoid doing that. Go out with your friends or family members. Get in touch with people you love and make you feel good about yourself and life. If you are feeling down, talk to somebody, and try not to keep what you are going through to yourself. Go out in nature; take a walk in the park or spend a few minutes outside every day. Do activities that you enjoy and lift your mood.

Regular doctor checkups

Let your doctor know about any side effects you are going through. If you feel like your mood starts changing drastically and it is affecting your life quality, talk about it with a professional. Maybe your dosage needs to be adjusted. If you’ve suffered from depression before, you should discuss that fact with your doctor. Ad resort to a mental health professional to give you more detailed tips about how to cope with depression.

Quit the drug

Phentermine diet pills can cause depression, and if anything seems to help, you may have to stop taking phentermine. Remember, phentermine is a habit-forming drug that can lead to addiction. You should not precipitate and stop taking phentermine without first consulting about it with a healthcare professional. Your doctor will probably create a quitting plan for you; maybe reducing the dosage little by little until you are off the drug.

Final thoughts

To answer the question: can phentermine cause depression? Yes, in rare circumstances, phentermine can lead to depression. In most cases, depression is developed due to the drug’s side effects or withdrawal symptoms after stopping the treatment. Even when suffering from depression due to phentermine is very unusual, it is best to check with your doctor if you feel mentally unwell while using the drug.

Taking care of your mental health is as essential as losing those extra pounds and achieving your weight loss goal. Stick to a healthy diet and a good exercise routine, but also find a place in that routine for things that improve your mood. If you want to start thriving in the benefits of phentermine and make sure you are doing it safely, schedule your appointment with us. We are always happy to guide you on your weight loss journey.

Nurse Walton


Nurse Walton

Born and raised in Chicago, IL, Chanay received her Practical Nurse licensure and went to work in clinical specialties such as Home Health, Assisted Living, Long-Term Care and Dialysis Centers. Through this work, she realized the importance of diet, nutrition and weight loss among her patients. This led her to open A Better Weigh, Inc. Medical Weight Loss Center in 2009.

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